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CLOMIPRAMINE AND METABOLITE

Test Code
CLOMIP
 
This test is a lab developed test. For further information, see the Compliance Remarks section below.
Synonyms
Anafranil; Desmethylclomipramine; Norclomipramine
SPECIMEN REQUIREMENTS
Container Type
Red top tube (plain)
Supply Item Number
1372
Specimen Type
Serum
Preferred Volume
0.5 mL
Emergency Minimum Volume
0.2 mL
Collection Procedure
Optimal time to collect sample: Draw 10-14 hours post-dose. If a divided dose is given, draw before morning dose.
Specimen Processing
Blood samples should be collected by venipuncture in a plain red top and serum samples must be allowed to clot naturally at room temperature. Separate serum from cells within 4 hours and place in separate polypropylene (not polystyrene) tube.
Store and Transport
Refrigerated
Stability
Room Temp 5 days  Refrigerated 1 week  Frozen (-20 °C) 1 month  Frozen (-70 °C) 1 year  
Unacceptable Condition
DO NOT use gel separator tubes (Corvac®, SST or equivalent) for the collection of blood samples for this test.
Alternate Specimens
Lavender (K2 or K3EDTA) or pink (K2EDTA)
Reference Laboratory
PAML
Reference Lab Test Code
LCA code 911163
CPT Codes
80335, (HCPCS G0480)
Interface Order Code
82491.Z14
Billing Code
CLOMIP
Test Schedule
Mon, Wed, Fri
Turnaround Time
1-3 days
Method
Tandem Mass Spectrometry
Reference Ranges
TitleDescriptorRangesUnits
Clomipramine70-200ng/mL
Desmethylclomipramine150-300ng/mL
Total (Clomipramine + Desmethylclomipramine)220-500ng/mL
Compliance Remarks
This test was developed and its performance characteristics determined by PAML. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. PAML is authorized under Clinical Laboratory Improvement Amendments (CLIA) to perform high-complexity testing.
Notes
Plasma concentrations vary widely among patients. The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well defined.

Interface Codes
typeorder codetest descriptionresult coderesult descriptionunitsdecimal placesloinc code
o82491.Z14Clomipramine and Metabolite
r82491.Z14Clomipramine and Metabolite82491.Z64Clomipramine (Anafranil)ng/mL03491-8
r82491.Z14Clomipramine and Metabolite82491.Z65Desmethyl-Clomipramineng/mL03536-0
r82491.Z14Clomipramine and Metabolite82491.Z66Total Clomipramineng/mL03493-4

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