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RISPERIDONE AND METABOLITE

Test Code
RIS
 
This test is a lab developed test. For further information, see the Compliance Remarks section below.
SynonymsRisperdal; Risperidone Metabolite; Total Active Moiety; 9-Hydroxyrisperidone; 9-OH-Risperidone
SPECIMEN REQUIREMENTS
Container TypeRed top tube (plain)
Supply Item Numberpicture1372
Specimen TypeSerum
Preferred Volume0.25 mL
Emergency Minimum Volume0.1 mL
Patient PrepOptimal time to collect sample: 0.5-1 hour before next oral dose at steady state. (Time to steady state: 3-5 days)
Specimen ProcessingSeparate serum from cells and transfer to a standard PAML aliquot tube.
Store and TransportRefrigerated
StabilityRoom Temp 2 weeks  Refrigerated 2 weeks  Frozen (-20 °C) 1 month  
Unacceptable ConditionDO NOT use gel separator tubes (Corvac®, SST or equivalent) for the collection of blood samples for this test.
Alternate SpecimensPlasma (EDTA or heparinized)
CPT Codes80342, (HCPCS G0480)
Interface Order Code82542.Z17
Billing CodeRIS
Test ScheduleMon, Wed, Fri
Turnaround Time1-3 days
MethodTandem Mass Spectrometry
Reference Ranges
TitleDescriptorRangesUnits
RisperidoneNot establishedng/mL
9-HydroxyrisperidoneNot establishedng/mL
Total (Risperidone and Metabolite)20-60ng/mL
Compliance RemarksThis test was developed and its performance characteristics determined by PAML. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. PAML is authorized under Clinical Laboratory Improvement Amendments (CLIA) to perform high-complexity testing.
NotesAdverse effects to risperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.

Interface Codes
typeorder codetest descriptionresult coderesult descriptionunitsdecimal placesloinc code
o82542.Z17Risperidone and Metabolite
r82542.Z17Risperidone and Metabolite82542.Z14Risperidoneng/mL09393-0
r82542.Z17Risperidone and Metabolite82542.Z159-Hydroxyrisperidoneng/mL09383-1
r82542.Z17Risperidone and Metabolite82542.Z16Risperidone and 9-Hydroxyng/mL09394-8

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