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Test Code
SynonymsDuragesic®; Fentanyl Metabolite; Sublimaze®
Container TypeRed top tube (plain) or Lavender top tube (EDTA) or green top tube (heparin)
Supply Item Numberpicture1372 or picture1222 or picture1398
Specimen TypeSerum, plasma, or whole blood
Preferred Volume0.25 mL
Emergency Minimum Volume0.05 mL
Specimen ProcessingSeparate serum or plasma from cells within two hours of collection and transfer to a standard PAML aliquot tube.
Store and TransportRefrigerated
StabilityRoom Temp 2 weeks  Refrigerated 2 weeks  Frozen (-20 °C) 2 weeks  
Unacceptable ConditionGel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
CPT Codes80354, (HCPCS G0480)
Interface Order Code83925.Z41
Billing CodeFENSTN.LCA
MethodLiquid Chromatography/Tandem Mass Spectrometry
Reference Ranges
FentanylImmediately following a single 2 mcg/kg IV dose: Up to 11 ng/mL, declining to 1 ng/mL after one hour. Following the application of 100 mcg/hour transdermal patch, serum levels (after an initial lag time of approximately six hours) of 0.8-2.6 ng/mL were maintained for more than 24 hours after application. Peak plasma levels following a single oral transmucosal dose (Fentanyl Oralet) of 15 mcg/kg to children: 2-4 ng/mL at 20 minutes. Substance(s) known to interfere with the identity and/or quantity of the reported result: 4-methylphenethyl acetyl fentanylng/mL
NorfentanylSubstance(s) known to interfere with the identity and/or quantity of the reported result: Benzyl Fentanylng/mL
NotesUse: Relief of pain adjunct to general or regional anesthesia moderate to moderately-severe pain. Indications for monitoring include the following: to confirm or identify suspected drug toxicity in chronic use, therapeutic misadventure, or accidental or intentional acute overdose; to aid in the identification of an unknown drug ingested in unknown quantities, drug identification and/or quantitation may be performed as an adjunct for patient management; to monitor selected patient groups at greater risk for analgesic drug toxicity or drug-to-drug interaction; to confirm complete drug absorption and adequate drug elimination as an adjunct to overdose management.

Interface Codes
typeorder codetest descriptionresult coderesult descriptionunitsdecimal placesloinc code
o83925.Z41Fentanyl and Metabolite
r83925.Z41Fentanyl and Metabolite83925.Z39Fentanylng/mL 74136-3
r83925.Z41Fentanyl and Metabolite83925.Z40Norfentanylng/mL 74137-1