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Test Code
SynonymsSerotonin Metabolite, Urine, Random; 5-Hydroxyindoleacetic Acid, Urine Random; 5HIAA, Urine, Random
Container TypeLeakproof plastic urine container
Supply Item Numberpicture1387
Specimen TypeUrine, Random
Preferred Volume5 mL
Emergency Minimum Volume1 mL
Patient PrepPatient should avoid avocados, bananas, plums, walnuts, pineapple, tomatoes, eggplant and medications that can interfere with the test (see Notes section below) for 3-4 days prior to and during collection. Consult your healthcare provider before changing your diet or discontinuing any medications.
Collection ProcedureCollect a random urine in a leakproof plastic urine container.
Specimen ProcessingAliquot 5 mL of a well-mixed urine into 2 aliquot tubes (5 mL each).
Store and TransportRefrigerated
StabilityRoom Temp 2 days  Refrigerated 2 weeks  Frozen (-20 °C) 2 months  
Unacceptable ConditionRoom temperature
LimitationsA pH less than 1 can interfere with assay perfomance.
CPT Codes83497, 82570
Interface Order Code83497.Z3
Billing CodeHIAUR
Test ScheduleTue, Thu
Turnaround Time2-6 days
MethodTandem Mass Spectrometry
Reference Ranges
Creatinine, Urine RandomMale39-259mg/dL
5-HIAA, UrineNo reference range establishedmg/L
5-HIAA, Urine Creatinine Ratio< 15mg/gCr
Compliance RemarksThis test was developed and its performance characteristics determined by PAML. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. PAML is authorized under Clinical Laboratory Improvement Amendments (CLIA) to perform high-complexity testing.
NotesFoods and medication may increase or decrease the concentration of 5-HIAA.

These medications have been associated with a decrease in 5-HIAA: methenamine, phenothiazine tranquilizers, homogentisic acid, acetic acid, heparin, monoamine oxidase inhibitors, methyldopa, and levodopa.

These medications have been associated with a increase in 5-HIAA: glycerol guaiacolate, mephenesin, phenacetin, acetaminophen (Tylenol), acetanilide, methocarbamol, and reserpine.

Interface Codes
typeorder codetest descriptionresult coderesult descriptionunitsdecimal placesloinc code
o83497.Z35-HIAA, Urine, Random
r83497.Z35-HIAA, Urine, Random82570.Z14Creatinine, Urine, mg/dLmg/dL02161-8
r83497.Z35-HIAA, Urine, Random83497.Z15-HIAA, Urine, mg/Lmg/L11694-9
r83497.Z35-HIAA, Urine, Random83497.Z25-HIAA, Urine, mg/gCRmg/gCR111145-0