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THYROID CANCER MONITORING

Test Code
THYCM
 
This test may reflex to additional tests depending upon the results of this test. An additional fee will be added if the reflex test is necessary.
SPECIMEN REQUIREMENTS
Container TypeSerum separator tube (gold, brick, SST, or corvac)
Supply Item Numberpicture1467
Specimen TypeSerum
Preferred Volume2.5 mL
Minimum Volume1.5 mL
Patient PrepNo sample should be drawn until at least 8 hours after last biotin administration
Specimen ProcessingSeparate serum from cells and transfer to a standard PAML aliquot tube.
Store and TransportAmbient (room temperature)
StabilityRoom Temp 6 days  Refrigerated 1 week  Frozen (-20 °C) 4 weeks  
Unacceptable ConditionHemolysis, lipemia, plasma, icteric
CPT Codes86800
Billing CodeTHYCM
Test ScheduleMon-Fri
Turnaround Time9-10 days
MethodECL/Reflex to Second Generation (Beckman Coulter) or LC/MS/MS
Test IncludesThyroglobulin Antibody, Electrochemiluminescence Reflex tests: Thyroglobulin, Second Generation (Beckman Coulter) or Thyroglobulin, LC/MS/MS
Reference Ranges
TitleRangeUnits
Thyroglobulin Ab, ECLLT or = 1IU/mL
This Thyroglobulin antibody test was performed using the Beckman Coulter Immunoenzymatic method. Values obtained from different assay methods cannot be used interchangeably. Thyroglobulin antibody levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease.
Thyroglobulin (Second Gen)LT 0.05ng/mL
TNP-Reflex testing not required.
Reference range applies to differentiated thyroid cancer patients following treatment.
This Thyroglobulin test was performed using the Beckman Coulter Chemiluminscent method. Values obtained from different assay methods cannot be used interchangeably. Thyroglobulin levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease.
Thyroglobulin, LC/MS/MSAdults: LT 0.4ng/mL
Reference range applies to differentiated thyroid cancer patients following treatment.
This Thyroglobulin test was performed by tandem mass spectrometry (LC/MS/MS) and does provide quantitative measurements of Thyroglobulin in the presence of anti-Tg antibodies. Values obtained from different assay methods cannot be used interchangeably. Thyroglobulin levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease.
Clinical SignificanceThe panel will first measure Tg Ab (Roche E170) an electrochemiluminescent assay and a highly sensitive test for the detection of endogenous anti-Tg antibodies. If the patient is Tg Ab negative, Tg will be measured using an immunoassay (Second Generation, Beckman Coulter) - also a highly sensitive assay with increased low-level sensitivity to 0.05 ng/mL. If the Tg Ab is positive, Tg will be measured by tandem mass spectrometry. The LC/MS/MS assay will provide quantitative measurement of Tg in the presence of Tg Ab.
Compliance RemarksThis test was developed and its performance characteristics have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. Performance characteristics refer to the analytical performance of the test.
Reflex Testing
Reflex ConditionReflex Test NameReflex CPT codesReflex Billing codes
If Thyroglobulin Antibody, ECL is LT or = 1 IU/mLThyroglobulin, Second Generation84432BTHCM2
If Thyroglobulin Antibody, ECL is GT 1 IU/mLThyroglobulin, LC/MS/MS84432BTHYCM

Interface Codes
typeorder codetest descriptionresult coderesult descriptionunitsdecimal placesloinc code
o86800.Z7Thyroid Cancer Monitoring
r86800.Z7Thyroid Cancer Monitoring86800.Z4Thyroglobulin Ab, ECLIU/mL 8098-6
r86800.Z7Thyroid Cancer Monitoring86800.Z5Tg (2nd gen), Beckmanng/mL219146-0
r86800.Z7Thyroid Cancer Monitoring86800.Z6Thyroglobulin, LC MS MSng/mL13013-0

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