THYROID CANCER MONITORING | |
| This test may reflex to additional tests depending upon the results of this test. An additional fee will be added if the reflex test is necessary. |
| SPECIMEN REQUIREMENTS | | | Container Type | Serum separator tube (gold, brick, SST, or corvac) | | Supply Item Number |  1467 | | Specimen Type | Serum | | Preferred Volume | 2.5 mL | | Minimum Volume | 1.5 mL | | Patient Prep | No sample should be drawn until at least 8 hours after last biotin administration | | Specimen Processing | Separate serum from cells and transfer to a standard PAML aliquot tube. | | Store and Transport | Ambient (room temperature) | | Stability | Room Temp 6 days Refrigerated 1 week Frozen (-20 °C) 28 days | | Unacceptable Condition | Hemolysis, lipemia, plasma, icteric | | CPT Codes | 86800 | | Billing Code | THYCM | | Test Schedule | Mon-Fri | | Turnaround Time | 9-10 days | | Method | ECL/Reflex to Second Generation (Beckman Coulter) or LC/MS/MS | | Test Includes | Thyroglobulin Antibody, Electrochemiluminescence
Reflex tests: Thyroglobulin, Second Generation (Beckman Coulter) or Thyroglobulin, LC/MS/MS | | Reference Ranges | | Title | Range | Units | | Thyroglobulin Ab, ECL | LT or = 20 | IU/mL | | | This Thyroglobulin antibody test was performed using the Roche Modular Analytics E170 Electrochemiluminescent method. Values obtained from different assay methods cannot be used interchangeably. Thyroglobulin antibody levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease. | | | Thyroglobulin (Second Gen) | LT 0.05 | ng/mL | | | TNP-Reflex testing not required. | | | Reference range applies to differentiated thyroid cancer patients following treatment. | | | This Thyroglobulin test was performed using the Beckman Coulter Chemiluminscent method. Values obtained from different assay methods cannot be used interchangeably. Thyroglobulin levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease. | | | Thyroglobulin, LC/MS/MS | Adults: LT 0.4 | ng/mL | | | Reference range applies to differentiated thyroid cancer patients following treatment. | | | This Thyroglobulin test was performed by tandem mass spectrometry (LC/MS/MS) and does provide quantitative measurements of Thyroglobulin in the presence of anti-Tg antibodies. Values obtained from different assay methods cannot be used interchangeably. Thyroglobulin levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease. |
| | Clinical Significance | The panel will first measure Tg Ab (Roche E170) an electrochemiluminescent assay and a highly sensitive test for the detection of endogenous anti-Tg antibodies. If the patient is Tg Ab negative, Tg will be measured using an immunoassay (Second Generation, Beckman Coulter) - also a highly sensitive assay with increased low-level sensitivity to 0.05 ng/mL. If the Tg Ab is positive, Tg will be measured by tandem mass spectrometry. The LC/MS/MS assay will provide quantitative measurement of Tg in the presence of Tg Ab. | | Compliance Remarks | This test was developed and its performance characteristics have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. Performance characteristics refer to the analytical performance of the test. | | Reflex Testing | | Reflex Condition | Reflex Test Name | Reflex CPT codes | Reflex Billing codes | | If Thyroglobulin Antibody, ECL is LT or = 20 IU/mL | Thyroglobulin, Second Generation | 84432 | BTHCM2 | | If Thyroglobulin Antibody, ECL is GT 20 IU/mL | Thyroglobulin, LC/MS/MS | 84432 | BTHYCM |
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| Interface Codes | | type | order code | test description | result code | result description | units | decimal places | loinc code | | o | 86800.Z7 | Thyroid Cancer Monitoring | | r | 86800.Z7 | Thyroid Cancer Monitoring | 86800.Z4 | Thyroglobulin Ab, ECL | IU/mL | | 8098-6 | | r | 86800.Z7 | Thyroid Cancer Monitoring | 86800.Z5 | Tg (2nd gen), Beckman | ng/mL | 2 | 19146-0 | | r | 86800.Z7 | Thyroid Cancer Monitoring | 86800.Z6 | Thyroglobulin, LC MS MS | ng/mL | 1 | 3013-0 |
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