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HELICOBACTER PYLORI AB IGA, IGG

Test Code
HPYAG
 
The American College of Gastroenterology no longer recommends serology for detection of H. pylori infection. A positive serology only determines that a patient has been exposed to H. pylori at some time in the past, but not whether the patient is currently infected. Studies indicate that about half of persons with a positive H. pylori serology do not have active infection (ACG,2007).Moreover, serology cannot be used to show that H. pylori have been successfully eradicated after treatment, as antibody levels commonly remain elevated for months to years after treatment.

The Urea Breath Test (UBT) and stool antigen test are recommended by both the American Gastroenterological Association (AGA) and the American College of Gastroenterologists (ACG) as the preferred non-invasive tests for diagnosis and confirmation of eradication. Both methods are highly sensitive and specific and useful for diagnosis therapeutic monitoring, and test of cure.
Important LinksHelicobacter pylori Infection Information
SynonymsH. pylori IgA and IgG; Campylobacter pylori IgA and IgG
SPECIMEN REQUIREMENTS
Container TypeSerum separator tube (gold, brick, SST, or corvac)
Supply Item Numberpicture1467
Specimen TypeSerum
Preferred Volume1 mL
Emergency Minimum Volume0.5 mL
Specimen ProcessingSeparate serum from cells ASAP and transfer to a standard PAML aliquot tube.
Store and TransportRefrigerated
StabilityRoom Temp 1 day  Refrigerated 2 weeks  Frozen (-20 °C) 1 month  
Unacceptable ConditionSeverely lipemic, contaminated, heat-inactivated, or hemolyzed specimens; avoid repeated freeze/thaw cycles
Alternate SpecimensSerum (plain red top tube or corvac)
CPT Codes86677 x 2
Interface Order Code86677.Z17
Billing CodeHPYAG
Test ScheduleMon-Sat
Turnaround Time1-3 days
MethodEIA
Reference Ranges
TitleDescriptorRanges
Helicobacter pylori Ab, IgA
Negative-no significant level of IgA antibody to H. pylori detected. 0.0-20.0
A negative result indicates no IgA antibody to H. pylori or levels below the detection limit of the assay. If a primary infection is suspected, another specimen should be collected in 4-6 weeks.
Equivocal Suggest repeat serologic testing in 10-14 days or order culture of biopsy material, breath test, or stool antigen test.20.1-24.9
Positive-IgA Ab to H. pylori detected, suggestive of active infection.25.0 or greater
Helicobacter pylori IgG and IgA seroconversion both occur about 2 months after infection. Symptomatic individuals who have a high titer of both IgG and IgA to H. pylori may have an active infection. However, a positive H. pylori IgA result can only suggest active infection and should be confirmed by bacterial isolation or other diagnostic testing.
Helicobacter pylori Ab, IgG
Negative-no significant level of IgG antibody to H. pylori detected. 0.0-20.0
A negative result indicates no IgG antibody to H. pylori or levels below the detection limit of the assay. If a primary infection is suspected, another specimen should be collected in 4-6 weeks.
Equivocal-Suggest repeat serologic testing in 10-14 days or order culture of biopsy material, breath test, or stool antigen test.20.1-24.9
Positive-IgG Ab to H. pylori detected, suggestive of previous exposure or active infection.25.0 or greater
A positive serologic result cannot distinguish current from previous infection, and cannot be used to assess response to therapy. Culture, breath, or stool antigen tests should be used for these purposes.

Interface Codes
typeorder codetest descriptionresult coderesult descriptionunitsdecimal placesloinc code
o86677.Z17Helicobacter Pylori Ab, IgA, IgG
r86677.Z17Helicobacter Pylori Ab, IgA, IgG86677Helicobacter pylori Ab, IgGISR15176-3
r86677.Z17Helicobacter Pylori Ab, IgA, IgG86677.Z16Helicobacter pylori Ab, IgAISR16420-4

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