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Test Code
SynonymsSerotonin Metabolite, Urine, Random; 5-Hydroxyindoleacetic Acid, Urine Random; 5HIAA, Urine, Random
Container TypeLeakproof plastic urine container
Supply Item Numberpicture1387
Specimen TypeUrine, Random
Preferred Volume5 mL
Minimum Volume1 mL
Patient PrepPatient should avoid avocados, bananas, plums, walnuts, pineapple, tomatoes and eggplant for 48 hours prior to and during collection. If possible, medication, including tryptophan supplements, should be withheld 3-4 days before collection.
Collection ProcedureCollect a random urine in a leakproof plastic urine container.
Specimen ProcessingAliquot 25 mL of a well-mixed 24-hour urine collection into a leakproof plastic urine container. Upon receipt, adjust pH to 1-4 with 6N HCl. Acidification is necessary to prevent decomposition of 5-HIAA.
Store and TransportRefrigerated
StabilityRoom Temp Unacceptable  Refrigerated Acidified: 1 week  Frozen (-20 °C) Acidified: 2 weeks  
Unacceptable ConditionRoom temperature
LimitationsA pH less than 1 can interfere with assay perfomance.
CPT Codes83497 x 1, 82570 x 1
Interface Order Code83497.Z3
Billing CodeHIAUR
Test ScheduleTue, Thu
Turnaround Time2-6 days
MethodHPLC/Electrochemical Detection/Enzymatic (IDMS traceable)
Test IncludesCreatinine, Urine Random, mg/dL; 5-HIAA, Urine,Random, mg/L; 5-HIAA(Calculation), mg/gCr
Reference Ranges
Creatinine, Urine Random19-311mg/dL
5-HIAA, Urine RandomNo reference range establishedmg/L
5-HIAA, Urine Random3-8 years1.2-16.2mg/gCr
9-12 years2.4-8.7
13-17 years1.8-5.5
Please note: A 24-hr urine collection is the preferred specimen. These reference ranges for random urine collections are based on literature review.
Compliance RemarksThis test was developed and its performance characteristics determined by PAML. The U.S. Food and Drug Administration (FDA) has not approved or cleared this test. However, FDA approval or clearance is currently not required for clinical use of this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. PAML is authorized under Clinical Laboratory Improvement Amendments (CLIA) to perform high-complexity testing.

Interface Codes
typeorder codetest descriptionresult coderesult descriptionunitsdecimal placesloinc code
o83497.Z35-HIAA, Urine, Random
r83497.Z35-HIAA, Urine, Random82570.Z14Creatinine, Urine, mg/dLmg/dL02161-8
r83497.Z35-HIAA, Urine, Random83497.Z15-HIAA, Urine, mg/Lmg/L11694-9
r83497.Z35-HIAA, Urine, Random83497.Z25-HIAA, Urine, mg/gCRmg/gCR111145-0